There is a total of 2341 clues beginning with up
- Up
 - Up to Ty Cobb
 - Up with at
 - Up 'til
 - Up 'til now
 - Up (for)
 - Up (for) or down (for)
 - Up (for), paradoxically
 - Up (or down) for something
 - Up (to)
 - Up (to), as a task
 - Up -- (cornered)
 - Up -- (trapped)
 - Up -- good
 - Up -- point
 - Up a creek
 - Up a lot
 - Up a tree
 - Up a tree, maybe
 - Up a tree, perhaps
 - Up a ___
 - Up a ___: stuck
 - Up a _____
 - Up above
 - Up again
 - Up against
 - Up against it
 - Up ahead, at sea
 - Up an offer, eg
 - Up an offer, on eBay
 - Up an' at 'em
 - Up and a little to the left, for short
 - Up and about
 - Up and about, usually
 - Up and about
 - Up and across
 - Up and around
 - Up and at 'em
 - Up and at it
 - Up and buzzing about
 - Up and coming
 - Up and doing
 - Up and doing
 - Up and down
 - Up and down like a ___
 - Up and down toy
 - Up and down, say: Abbr
 - Up and going
 - Up and moving
 - Up and open-eyed
 - Up and out of bed
 - Up and running
 - Up and up
 - Up and __ (on the move)
 - Up and ___
 - Up and ___ (active)
 - Up and ___ (active)
 - Up and ___ (busy)
 - Up and ___!
 - Up and ___
 - Up and ___: all better
 - Up and ___: Slang
 - Up and ____!
 - Up at night, as owls
 - Up beat?
 - Up by a run, say
 - Up chuck?
 - Up close
 - Up close and personal
 - Up close and personal?
 - Up day on Wall Street
 - Up doing things
 - Up end?
 - Up for
 - Up for a drive?
 - Up for anything
 - Up for auction
 - Up for being up to no good
 - Up for bidding
 - Up for bids
 - Up for debate
 - Up for debate, as a bill
 - Up for discussion
 - Up for grabs
 - Up for grabs, as convention delegates
 - Up for grabs, in a way
 - Up for grabs, politically
 - Up for it
 - Up for negotiation
 - Up for payment
 - Up for sale in "The Abbé Constantin"
 - Up for something
 - Up for the challenge
 - Up for the day
 - Up for the job
 - Up for __
 - Up for ___
 - Up from 24-Across
 - Up from bed
 - Up from Méjico