There is a total of 21143 clues beginning with lo
- Lose every set of a tennis match 6-0?
- Lose everything
- Lose face
- Lose face?
- Lose feathers
- Lose feathers or skin
- Lose feathers, in London
- Lose feathers
- Lose feeling
- Lose firmness
- Lose firmness, in a way
- Lose fizz
- Lose flab
- Lose focus
- Lose focus, in a way
- Lose focus, with "out"
- Lose footing
- Lose for a while
- Lose force
- Lose force
- Lose forward momentum
- Lose forward traction
- Lose freshness
- Lose freshness, as a flower
- Lose freshness, as lettuce
- Lose freshness
- Lose friends
- Lose fur
- Lose greenness
- Lose ground
- Lose ground after convalescing
- Lose ground in the standings
- Lose ground, in a Paul Simon song
- Lose ground, literally
- Lose ground, mentally
- Lose ground?
- Lose hair
- Lose hair or fur
- Lose hair, as a dog
- Lose hair, like a dog
- Lose heart
- Lose heat
- Lose hold of
- Lose hope
- Lose hope
- Lose iciness
- Lose ignominiously, in slang
- Lose illegally
- Lose impact
- Lose in a big way
- Lose in a chase
- Lose in a confrontation, maybe
- Lose in a dice game, with "out"
- Lose in a logrolling match, say
- Lose in a staring contest
- Lose in great amounts
- Lose in one's drawers
- Lose influence
- Lose inhibitions
- Lose intensity
- Lose intensity
- Lose intentionally
- Lose interest
- Lose interest in
- Lose interest
- Lose it
- Lose it all
- Lose it big-time
- Lose it completely
- Lose it during a debate
- Lose it in an emergency
- Lose it in the clutch
- Lose it, and a hint to the last words of 18-, 27-, 48- and 63-Across
- Lose it, and title of this puzzle
- Lose it, with "out"
- Lose its attraction
- Lose its fizz, as soda
- Lose its luster
- Lose its solidity
- Lose juice entirely
- Lose knowledge of
- Lose liquid
- Lose liquidity
- Lose liquidity, in a way
- Lose little by little
- Lose locks
- Lose luster
- Lose luster, as colors
- Lose lustre
- Lose minutes
- Lose moisture
- Lose moisture, in a way
- Lose moisture
- Lose momentarily
- Lose momentum
- Lose money
- Lose money on "Jeopardy!"
- Lose money on "Jeopardy!," eg
- Lose muscle tone
- Lose no games