There is a total of 6259 clues beginning with is
- Issue for a programmer
- Issue for a speech coach, perhaps
- Issue for an ophthalmologist
- Issue for arguing asses?
- Issue for Boston partyers
- Issue for Jim Hahn to tackle
- Issue for Marco Rubio, vis-a-vis his Senate voting
- Issue for Mayor Riordan
- Issue for Michelle Obama
- Issue for NOW
- Issue for one who stinks, familiarly?
- Issue for the media?
- Issue for the Occupy Wall Street movement
- Issue forth
- Issue forth with force
- Issue forth, or hide away
- Issue forth
- Issue from
- Issue from the throne
- Issue from
- Issue halves
- Issue in a locker room, maybe
- Issue in a murder trial
- Issue in Congress
- Issue in kids' smartphone usage
- Issue in May-December romances
- Issue in porn?
- Issue in rays
- Issue in the Iowa caucuses
- Issue materiel
- Issue of 1765
- Issue of 1964–5
- Issue of 1993
- Issue of a book
- Issue of a sibling
- Issue of a US beauty magazine historic for being the first sent to post-Soviet Russia?
- Issue of concern to feminists
- Issue of concern to the AARP: Var
- Issue of MADD
- Issue of most newspapers
- Issue often in dispute on "The Jerry Springer Show"
- Issue on a stand, informally
- Issue opener?
- Issue pikes and poleaxes, eg
- Issue possibility
- Issue shares, initially
- Issue short rations
- Issue side
- Issue stemming from Tenth Amendment
- Issue suddenly
- Issue that is hard to handle
- Issue that one may 49-Down
- Issue to avoid
- Issue to debate
- Issue to discuss
- Issue too risky to deal with
- Issue ultimatums, eg
- Issue violently
- Issue violently, as a volcano
- Issue violently, as matter from a volcano
- Issue walking papers to
- Issue with a new look, maybe
- Issue with image quality, informally?
- Issue's most important element and a hint to 17-, 30-, 36- and 47-Across
- Issue, as a decree
- Issue, as a verdict
- Issue, as an insult
- Issue, as from a source
- Issue, as light
- Issue, as paper money
- Issue, perhaps
- Issue, with "out"
- Issue
- Issue: Abbr
- Issue; arise
- Issued
- Issued 10-Across
- Issued a challenge to
- Issued a command
- Issued a command to
- Issued a decision
- Issued a gag order
- Issued a gag order on
- Issued a ticket to
- Issued a ukase
- Issued again
- Issued an informal greeting
- Issued an order
- Issued an order to
- Issued an ultimatum
- Issued decree
- Issued forth
- Issued forth
- Issued from a shoe
- Issued from the echo chamber
- Issued in rays
- Issued orders, sergeant-style
- Issued pound notes?
- Issued temporarily
- Issued walking papers