There is a total of 6259 clues beginning with is
- Isle of Wight seaport
- Isle of Wight settlers
- Isle of Youth dweller
- Isle of __
- Isle of __ (Avalon)
- Isle of ___
- Isle of ___ (England)
- Isle of ___ (historic region of England)
- Isle of ___ (part of Cambridgeshire, England)
- Isle of ___, county in E England
- Isle of ___, England
- Isle of ___, in England
- Isle of ___, off Cuba
- Isle of ___, part of Cambridgeshire
- Isle of ___, Scotland
- Isle of ___, West Indies
- Isle of ___
- Isle of ____
- Isle of _____
- Isle of _____, England
- Isle off Alaska
- Isle off coast of Ireland
- Isle off England
- Isle off Italy
- Isle off Naples
- Isle off New Caledonia
- Isle off Scotland
- Isle off Sicily
- Isle off the lower boot
- Isle off the Scottish coast
- Isle off the Sorrento Peninsula
- Isle off the Tuscan coast
- Isle off Tuscany
- Isle off Venezuela
- Isle of___in Irish Sea
- Isle on the Gulf of Naples
- Isle on the Ouse
- Isle on the Ouse
- Isle on which Apollo was born
- Isle on which Augustus lived
- Isle or City
- Isle or terrier
- Isle or terrier type
- Isle Royale grazer
- Isle Royale Natl Pk site
- Isle ruled by Morgan le Fay
- Isle serenaded in "South Pacific"
- Isle south of Southampton
- Isle such as Bikini
- Isle surrounder
- Isle taken with Tarawa
- Isle used as a base by Xerxes
- Isle W of Kiska
- Isle W of Sumatra
- Isle where Homer is buried, supposedly
- Isle where Macbeth is buried
- Isle where Napoleon was exiled
- Isle where Saint Columba died
- Isle where several Scottish kings are buried
- Isle with a lagoon
- Isle with a lagoon
- Isle __
- Isle __ (spot off England)
- Isle __ National Park
- Isle ___
- Isle ___ (site off England)
- Isle ___ National Park
- Isle ___, in the Irish Sea
- Isle ___
- Isle, part of County Donegal
- Isle-dweller's transport
- Isle-studded bay off Portland, Me
- Isle
- Isle: Fr
- Isle: Var
- Isled
- Isles
- Isles defending Alaska
- Isles in Galway Bay
- Isles including Inishmore
- Isles of Portugal
- Isles of the Pacific
- Isles of the ___
- Isles of __: Gulf of Maine locale
- Isles off Ireland
- Isles off Ireland
- Isles off S W New Guinea
- Isles S of Kamchatka
- Isles south of Formosa
- Isles, to 77-Across's Rizzoli
- Isles, to a Brit
- Isles
- Islet
- Islet in a river (used in place names)
- Islet in a river or lake
- Islet in la mer
- Islet in the Thames
- Islet on a coral reef
- Islet
- Islet: Dial