There is a total of 6259 clues beginning with is
- Is shy by
- Is shy, in a way
- Is shy, so to speak
- Is sibilantly challenged?
- Is sick
- Is sick of
- Is sick with
- Is sickeningly sentimental
- Is sickeningly sweet
- Is sickly
- Is sickly sweet
- Is sidelined
- Is significant enough
- Is silently furious
- Is situated
- Is situated (in)
- Is situated
- Is skeptical about
- Is slack-jawed
- Is slow-paced
- Is sluggish
- Is smart
- Is smitten by
- Is snippy and uncooperative
- Is snoopy
- Is snug
- Is so bold as
- Is so inclined
- Is so inclined
- Is so minded
- Is sociable
- Is sociable at a party
- Is sociable, in a way
- Is solicitous
- Is solicitous
- Is somewhat effective
- Is somewhat remorseful
- Is soothing
- Is sore
- Is sorrowful
- Is sorry
- Is sorry about
- Is sorry for
- Is sorry for
- Is sound in principle
- Is South American?
- Is Spanish?
- Is sparing
- Is sparing
- Is spellbinding
- Is spitting mad, figuratively
- Is sporting
- Is staggered
- Is standing and speaking, at a meeting
- Is staying overnight (at)
- Is steamed
- Is stertorous
- Is still
- Is still going
- Is still in the running
- Is still in the running for
- Is still on the water
- Is stimulated
- Is stingy
- Is stingy
- Is stopped on the field
- Is strabismic
- Is stranded
- Is stricken
- Is stricken with
- Is strong, in a way
- Is strongly held, as a belief
- Is stuck on something
- Is stunned
- Is subjected to a series of attacks
- Is subtly misleading, or what each of 23- and 47-Across does, figuratively and literally
- Is successful
- Is successful at luring
- Is successful at musical chairs
- Is successful in
- Is successful in a lawsuit
- Is successful
- Is successfully interrogated
- Is suddenly seen
- Is suffering
- Is suffering from
- Is suffering from, as a cold
- Is sufficient
- Is suggestive (of)
- Is suitable
- Is suitable (for)
- Is suitable (with "with")
- Is suitable for
- Is suitable to
- Is suitable
- Is suited
- Is sullen and silent
- Is super heroic
- Is super into
- Is super into, in modern parlance