There is a total of 6259 clues beginning with is
- Is irate
- Is irritated
- Is it true you plan to shave your beard?
- Is itinerant
- Is jealous of
- Is joyful, maybe
- Is joyful, perhaps
- Is jubilant
- Is just awful
- Is just crazy about
- Is just joking
- Is just part of the package, informally
- Is just right
- Is kaput
- Is king
- Is knocked for a loop
- Is lachrymose
- Is lacking
- Is lacking
- Is laid up
- Is laid up in bed, maybe
- Is laid up with
- Is larcenous
- Is Latinized
- Is law-abiding
- Is led to believe
- Is leery of
- Is left
- Is left hanging
- Is left on base
- Is left to, as a responsibility
- Is left undecided
- Is left with
- Is left without a choice
- Is legally entitled
- Is less than honest
- Is less vigilant
- Is licked by
- Is light
- Is light, in a way
- Is lightfingered
- Is lighthearted
- Is like
- Is like a moonstone
- Is like a stink bomb
- Is like a stumped puzzle solver?
- Is like the Shadow?
- Is likely to deliver soon
- Is lionlike
- Is literate
- Is litigious
- Is living the dream
- Is loaded
- Is located
- Is logical
- Is lonesome for
- Is looking tired
- Is looming
- Is Lord
- Is losing to
- Is lost
- Is loudly angry with
- Is low around the waist, as pants
- Is loyal regarding
- Is loyal to
- Is mad about
- Is mad for
- Is made up
- Is made up (of)
- Is made up of
- Is made up
- Is magnetic
- Is mailed out
- Is malicious to
- Is malicious toward
- Is mannerly
- Is mathematical
- Is mathematically challenged
- Is meddlesome
- Is melodramatic
- Is mendacious
- Is merciful
- Is messy
- Is meticulous, with 53-Across
- Is metrically sound
- Is mid-sentence?
- Is mildly embarrassed
- Is mindful of
- Is miserable about
- Is miserly
- Is missing
- Is mistaken
- Is mistaken
- Is moderately successful
- Is monomaniacal
- Is moodily silent
- Is morally bound to
- Is morally obligated to
- Is more efficient
- Is more efficient, in a way