There is a total of 27405 clues beginning with fi
- First responder, maybe
- First responder, often
- First responder, perhaps
- First responder, say: Abbr
- First responder, to many
- First responders
- First responders (abbr)
- First responders' destinations, briefly
- First responders' initials
- First responders' letters
- First responders, at times
- First responders, briefly
- First responders, for short
- First responders, often (abbr)
- First responders: Abbr
- First response to a call
- First rib donor
- First rib donor?
- First rib-loser
- First right-handed batter to reach 500 home runs
- First robin to arrive?
- First rock band whose members received Kennedy Center Honors
- First rock from the sun
- First rock star to appear on a US stamp
- First Roman emperor, 27 BC to AD 14
- First Roman to be deified
- First romance, often
- First roofed ballpark
- First roomie, often
- First Roosevelt VP
- First root beer to come in half-gallons
- First round draft pick?
- First round exemptions, in tournaments
- First round of chips
- First round of voting
- First round pick of the Magic
- First row
- First rule of lion taming?
- First ruler in Egypt's Nineteenth Dynasty
- First ruler of a united Hawaii
- First ruler of all Egypt
- First ruler of the Slavs
- First run of the still
- First runner-up on "American Idol"
- First Russian czar
- First Russian Literature Nobelist
- First Russian Literature Nobelist Ivan
- First Russian Orthodox saint
- First Russian ruler to take the title "Czar," 1547
- First Russian to be called "czar"
- First Russian to orbit Earth
- First Russian tsar
- First sacrament
- First saint canonized by a pope
- First saint canonized by a pope, in 993
- First saint of the Russian Orthodox Church
- First satellite
- First satellite to orbit Earth
- First satellite to transmit a phone call through space, 1962
- First Scandinavian Olympic venue
- First scene in "La Bohème"
- First scene of 21 Across
- First sch
- First sch to win 100 NCAA championships, across all sports
- First schizophrenic problem?
- First school for some, briefly
- First score in a tennis game
- First Scorsese/DeNiro collaboration
- First screen Tarzan
- First screenplay by 20-Across
- First seagoing vessel, in myth
- First Seahawk quarterback Jim
- First seaport of invasion
- First season
- First seat of English government in India
- First second son
- First second wife
- First Secretary General of the UN
- First Secretary of Education Hufstedler
- First secretary of HEW, 1953, ___ Culp Hobby
- First secretary of Homeland Security
- First secretary of state
- First Secretary of Transportation
- First Secretary of War
- First section
- First section of a form, perhaps
- First section of a novel
- First section of a tome
- First section
- First Secy of the Treasury, 1789–95
- First seducer
- First segment of a literary work
- First self-propelled astronaut
- First semester
- First semester offerings
- First senator in space
- First sentence of a news story
- First sequel to win Best Picture, with "The"
- First sequel's sequel