There is a total of 27406 clues beginning with fi
- First dynasty to unify China
- First Earl of Avon
- First Earl of Beaconsfield
- First Earl of Chatham
- First Earl of Chatham
- First Earl of Leicester
- First earring, maybe
- First earth orbiter
- First earthly garden
- First ed
- First edition, usually
- First editor of "The Overland Monthly"
- First editor of Ms
- First editor of the "Tatler"
- First editor of The Atlantic Monthly
- First editor of the magazine George
- First editor of The New Yorker
- First efforts at compromise
- First Egyptian king
- First Egyptian to win a Nobel Prize
- First elected Congresswoman Jeannette
- First elected governor of Alaska
- First elected governor of Alaska
- First elected member at Cooperstown
- First electronic computer
- First electronic computer, unveiled in 1946
- First electronic musical instrument
- First electronic stock market
- First elements
- First emergency craft captain
- First Emmy song hit: 1955
- First Emmy-winning song
- First emperor of Austria
- First emperor of Brazil
- First Emperor of Brazil, 1822–31
- First emperor of China
- First emperor of Rome
- First emperor of Rome
- First emperor of Russia
- First encounter in a romcom
- First English Channel swimmer
- First English child born in America
- First English child born in America
- First English colony in America
- First English commander to see the Pacific
- First English globe-girdler
- First English king
- First English King, so called
- First English printer
- First Englishman to circumnavigate the globe, 1580
- First Englishman to sail around the globe
- First Englishman to sail around the world
- First entry in "Who's Who in the Bible"
- First entry in a 24-film franchise
- First entry in a contract
- First entry in a crossword to a constructor
- First episode
- First episode in a TV series
- First episode of many a series
- First episodes
- First established
- First estate
- First etc in football: Abbr
- First European explorer to see New Zealand
- First European nation to win the World Cup
- First European to cross America
- First European to cross the Mississippi
- First European to discover Alaska
- First European to discover New Zealand
- First European to discover Tahiti
- First European to enter New York Bay
- First European to land in North America
- First European to reach India by sea
- First European to reach India by sea (1497–99)
- First European to reach New Zealand
- First European to reach the Pacific
- First European to reach the shores of America
- First European to round the Cape of Good Hope
- First European to sail to India
- First European to see the Mississippi
- First event in a series
- First eviction site
- First ex-wife of Donald Trump
- First excuse
- First experience
- First explorer of North America's Southwest
- First explorer to sail directly from Europe to India
- First extra baseball inning
- First extra inning
- First fall guy?
- First Families of Virginia surname
- First family
- First family after the Garfields
- First family as of 2009
- First Family at Albany
- First family before the Wilsons
- First family during the Mexican American War
- First family father
- First family grandson