There is a total of 27406 clues beginning with fi
- First and only female Speaker of the House
- First and only fictional group to have a #1 hit song, with "The"
- First and only president of the Republic of Hawaii
- First and pocket
- First and reverse
- First and reverse, eg
- First and second
- First and second for example
- First and Second Avenues area, in Manhattan
- First and Second places?
- First and second, eg
- First and second, for two
- First and third
- First and third, eg
- First and worst tsar?
- First and __
- First and __: most important
- First and ___
- First and ___ (football term)
- First animal conservationist
- First animal in the Chinese zodiac
- First animal in the dictionary
- First animal of the Chinese zodiac
- First animal rescue vessel?
- First animal shelter
- First animal sound in "Old MacDonald"
- First animal up on the farm, usually
- First animal, in a way
- First animal?
- First animated dinosaur (1914)
- First animated film from DreamWorks
- First anniversary gift
- First anniversary gift for a zookeeper?
- First anniversary symbol
- First answer in the first-ever published crossword
- First anti-AIDS drug
- First antibacterial soap
- First antibacterial soap brand
- First antiparticle discovered
- First antiseptic surgeon
- First apartment, perhaps
- First ape trained to communicate with humans in sign language
- First appearance
- First appearance of Sid the sloth
- First appearance, as of dawn
- First appearance, as of dawn
- First appearance, as of symptoms
- First appearance
- First appearances
- First apple polisher?
- First apple user?
- First application blank
- First application line to fill in
- First Arab country to have sanctions imposed on it by the Arab League
- First Arabian letter
- First Arabic letter
- First Arabic letter
- First arboretum
- First area to fill in on a form
- First Army rank of 39-Across
- First arrival
- First Arthur C Clarke Award winner
- First article in a contract
- First artificial satellite
- First artist whose first six albums debuted at #1 on the Billboard 200
- First Asian city to host the Winter Olympics
- First Asian country to rule in favor of same-sex marriage
- First Asian tennis player to be ranked #1 in singles
- First Asian-American Cabinet member
- First Asian-American NBA champion Jeremy
- First Asian-American to serve in the Cabinet
- First aspirin maker
- First assembly instruction
- First assembly-line car
- First assembly-line carmaker
- First assemblyman?
- First Astaire-Rogers musical
- First asteroid
- First asteroid discovered
- First asteroid discovered
- First asteroid ever discovered
- First asteroid landed on by a NASA craft
- First asteroid landed on by a spacecraft
- First asteroid orbited by a NASA spacecraft
- First asteroid to be landed on by a spacecraft
- First asteroid to be orbited by an artificial satellite
- First astrological sign
- First astronaut to make four spaceflights
- First at the North Pole
- First at the South Pole, 1911
- First athlete to appear on a 116 Across
- First athlete to appear on the cover of Time magazine
- First athlete to lend his name to a video game
- First athlete to win seven gold medals in a single Olympics
- First atomic submarine
- First atomic-powered submarine, now under construction
- First attempt
- First author of the "Oz" books
- First authority