The most common and most likely answer to this crossword clue is the 3 letter word DOC which also is the latest solution we found used in New York Times in 2025.
"What's up ___?" crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters |
|---|---|---|
| DOC | 100 % | 3 |
Why may DOC be the right solution?
The phrase "What's up, ___?" is a common greeting in which the blank is typically filled with "Doc" as a slang term for a doctor. This is a reference to the iconic character Dr. Emmett Brown from the movie "Back to the Future."
Words with a meaning similar to the clue: "What's up ___?"
These words may or may not be a possible solution to this crosswords clue.- whassup
- whatcha
- whaddaya
- wassup
- what with
- so what
- what about
- well up
- hello
- watcha
- hellos
- up for
Crossword Answer definitions
DOC noun- A doctor.
- (usually in the plural) A document, especially (in professional jargon) a piece of technical documentation or legal evidence.
- A documentary.
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution