The most common and most likely answer to this crossword clue is the 5 letter word AFINE which also is the latest solution we found used in Newsday in 2012.
"That's __ how-do-you-do!" crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| AFINE | 100 % | 5 | 
Words with a meaning similar to the clue: "That's __ how-do-you-do!"
These words may or may not be a possible solution to this crosswords clue.- comment
 - then
 - know
 - what
 - can
 - aloha
 - analysis
 - cool
 - direction
 - hang
 - harmony
 - hello
 
Crossword Answer definitions
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution