The most common and most likely answer to this crossword clue is the 8 letter word CAFFEINE which also is the latest solution we found used in Newsday in 2006.
Substance in 95 Across crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| CAFFEINE | 100 % | 8 | 
Words with a meaning similar to the clue: Substance in 95 Across
These words may or may not be a possible solution to this crosswords clue.- dielectric
 - neurotransmitter
 - smear
 - active transport
 - tympanum
 - passive transport
 - permease
 - air
 - overcast
 - ethyl alcohol
 - neutral spirits
 - salamis
 
Crossword Answer definitions
CAFFEINE noun- An alkaloid, C8H10N4O2, found naturally in tea and coffee plants which acts as a mild stimulant on the central nervous system.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution