The most common and most likely answer to this crossword clue is the 4 letter word HOLY which also is the latest solution we found used in CrossSynergy in 2004.
Of interest to the Pope crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| HOLY | 100 % | 4 | 
Words with a meaning similar to the clue: Of interest to the Pope
These words may or may not be a possible solution to this crosswords clue.- reservation
 - languor
 - errancy
 - gregory
 - karol
 - center
 - nature
 - realm
 - rest
 - rested
 - ablegate
 - allocution
 
Crossword Answer definitions
HOLY noun- A thing that is extremely holy; used almost exclusively in Holy of Holies.
 
- Dedicated to a religious purpose or a god.
 - Revered in a religion.
 - Morally perfect or flawless, or nearly so.
 - Separated or set apart from (something unto something or someone else).
 - Set apart or dedicated for a specific purpose, or for use by a single entity or person.
 - Used as an intensifier in various interjections.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution