The most common and most likely answer to this crossword clue is the 7 letter word SICKEST which also is the latest solution we found used in New York Times in 1995.
Most afflicted crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| SICKEST | 100 % | 7 | 
Words with a meaning similar to the clue: Most afflicted
These words may or may not be a possible solution to this crosswords clue.- touch
 - susceptible
 - acute
 - down
 - miserable
 - nauseous
 - scale
 - sneezy
 - sorely
 - distressed
 - sciatic
 - smitten
 
Crossword Answer definitions
SICKEST adjective- Having an urge to vomit.
 - In poor health.
 - Mentally unstable, disturbed.
 - In bad taste.
 - Tired of or annoyed by something.
 - Very good, excellent, awesome, badass.
 - In poor condition.
 - Failing to sustain adequate harvests of crop, usually specified.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution