The most common and most likely answer to this crossword clue is the 4 letter word OHIO which also is the latest solution we found used in USA Today in 2000.
Major US river crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters |
|---|---|---|
| OHIO | 100 % | 4 |
Words with a meaning similar to the clue: Major US river
These words may or may not be a possible solution to this crosswords clue.- ohio
- mississippi
- amazon
- gila
- mississippi river
- detroit
- rhine
- rhone
- congo
- rhein
- ruhr
- tay
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution