The most common and most likely answer to this crossword clue is the 5 letter word AORTA which also is the latest solution we found used in American Values Club in 2015.
It comes straight from the heart crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| AORTA | 100 % | 5 | 
Words with a meaning similar to the clue: It comes straight from the heart
These words may or may not be a possible solution to this crosswords clue.- ahead
 - day
 - square
 - heads
 - line
 - apex
 - present
 - issue
 - set
 - are
 - head
 - sets
 
Crossword Answer definitions
AORTA noun- The great artery which carries the blood from the heart to all parts of the body except the lungs; the main trunk of the arterial system.
 - The liveliest part of something.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution