The most common and most likely answer to this crossword clue is the 8 letter word CAFFEINE which also is the latest solution we found used in CrossSynergy in 2003.
It can keep you up crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| CAFFEINE | 100 % | 8 | 
Words with a meaning similar to the clue: It can keep you up
These words may or may not be a possible solution to this crosswords clue.- sustain
 - tab
 - lie
 - hold
 - support
 - move
 - mind
 - thanks
 - take
 - sky
 - pursue
 - share
 
Crossword Answer definitions
CAFFEINE noun- An alkaloid, C8H10N4O2, found naturally in tea and coffee plants which acts as a mild stimulant on the central nervous system.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution