The most common and most likely answer to this crossword clue is the 3 letter word CPU which also is the latest solution we found used in Washington Post in 2006.
IBM "brain" crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| CPU | 100 % | 3 | 
Words with a meaning similar to the clue: IBM "brain"
These words may or may not be a possible solution to this crosswords clue.- cpu
 - think
 - mac
 - nec
 - pcs
 - apple
 - blue
 - cos
 - ebcdic
 - lotus
 - typist
 - esc
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution