The most common and most likely answer to this crossword clue is the 4 letter word MESA which also is the latest solution we found used in New York Times in 2019.
Four-letter US city with the highest population crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| MESA | 100 % | 4 | 
Words with a meaning similar to the clue: Four-letter US city with the highest population
These words may or may not be a possible solution to this crosswords clue.- lucerne
 - block
 - london
 - tabriz
 - quart
 - iquique
 - amritsar
 - florence
 - town
 - lisbon
 - pinochle
 - aswan
 
Crossword Answer definitions
MESA noun- Flat area of land or plateau higher than other land, with one or more clifflike edges.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution