The most common and most likely answer to this crossword clue is the 4 letter word DUOS which also is the latest solution we found used in New York Times in 1964.
Four-handed pieces: Mus crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| DUOS | 100 % | 4 | 
Words with a meaning similar to the clue: Four-handed pieces: Mus
These words may or may not be a possible solution to this crosswords clue.- bones
 - duet
 - tetralogy
 - rook
 - quadrille
 - eod
 - rod
 - whist
 - mouse
 - piano
 - base
 - open
 
Crossword Answer definitions
DUOS noun- Two people who work or collaborate together as partners; especially, those who perform music together.
 - Any pair of two people.
 - Any cocktail consisting of a spirit and a liqueur.
 - A song in two parts; a duet.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution