The most common and most likely answer to this crossword clue is the 6 letter word MESCAL which also is the latest solution we found used in New York Times in 1975.
Cactus of Southwest crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| MESCAL | 100 % | 6 | 
Words with a meaning similar to the clue: Cactus of Southwest
These words may or may not be a possible solution to this crosswords clue.- mescal
 - saguaro
 - rainbow cactus
 - ocotillo
 - mesa
 - acanthocereus pentagonus
 - acanthocereus tetragonus
 - cereus
 - cholla
 - crab cactus
 - easter cactus
 - echinocactus
 
Crossword Answer definitions
MESCAL noun- A Mexican alcoholic drink distilled from the fermented juice of the agave.
 - The peyote cactus.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution