The most common and most likely answer to this crossword clue is the 5 letter word OPRAH which also is the latest solution we found used in USA Today in 1997.
Afternoon TV mainstay crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| OPRAH | 100 % | 5 | 
Words with a meaning similar to the clue: Afternoon TV mainstay
These words may or may not be a possible solution to this crosswords clue.- oprah
 - soap
 - carson
 - anchor
 - tea
 - dan rather
 - diane sawyer
 - peter jennings
 - news
 - sitcom
 - ann
 - dinner
 
Crossword Answer definitions
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution
More clues leading to the result OPRAH
- Talk queen
 - First name in talk shows
 - Talk show host
 - Her company is an ananym of her name
 - Brilliantly colored sashimi fish (or ... host who gave 30-Down his start)
 - "Selma" costar/producer
 - Big name in book clubs
 - First African-American to top Entertainment Weekly's 101 Most Powerful list
 - First black billionaire
 - OWN owner