The most common and most likely answer to this crossword clue is the 6 letter word UPENDS which also is the latest solution we found used in Newsday in 2015.
Affects radically crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| UPENDS | 100 % | 6 | 
Words with a meaning similar to the clue: Affects radically
These words may or may not be a possible solution to this crosswords clue.- bunt
 - fever
 - plague
 - dramatically
 - fundamentally
 - opposite
 - overturn
 - overturned
 - overturning
 - revolutionize
 - strike
 - upend
 
Crossword Answer definitions
UPENDS verb- To end up; to set on end.
 - To tip or turn over.
 - To destroy, invalidate, overthrow, or defeat.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution