The most common and most likely answer to this crossword clue is the 8 letter word UPENDING which also is the latest solution we found used in New York Times in 2018.
Affecting radically crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| UPENDING | 100 % | 8 | 
Words with a meaning similar to the clue: Affecting radically
These words may or may not be a possible solution to this crosswords clue.- opposite
 - revolutionize
 - strike
 - upend
 - cold
 - cutting
 - deep
 - feeling
 - heady
 - important
 - poignant
 - sensible
 
Crossword Answer definitions
UPENDING verb- To end up; to set on end.
 - To tip or turn over.
 - To destroy, invalidate, overthrow, or defeat.
 
- An act of overthrowing or turning over.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution