The most common and most likely answer to this crossword clue is the 4 letter word MASS which also is the latest solution we found used in New York Sun in 2003.
Affecting a great many crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| MASS | 100 % | 4 | 
Words with a meaning similar to the clue: Affecting a great many
These words may or may not be a possible solution to this crosswords clue.- epidemic
 - mania
 - numerous
 - triple
 - sweeping
 - universal
 - panic
 - panicked
 - double
 - far
 - lots
 - multifarious
 
Crossword Answer definitions
MASS noun- (physical) Matter, material.
 - A large quantity; a sum.
 
- To form or collect into a mass; to form into a collective body; to bring together into masses; to assemble.
 - To have a certain mass.
 
- Involving a mass of things; concerning a large quantity or number.
 - Involving a mass of people; of, for, or by the masses.
 
- The Eucharist, now especially in Roman Catholicism.
 - Celebration of the Eucharist.
 - (usually as the Mass) The sacrament of the Eucharist.
 - A musical setting of parts of the mass.
 
- To celebrate mass.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution