The most common and most likely answer to this crossword clue is the 5 letter word UPEND which also is the latest solution we found used in Newsday in 2004.
Affect radically crossword clue answers
Here's a list of possible crossword answers ranked by the most likely to least likely.
| Answer | Likelyness | Letters | 
|---|---|---|
| UPEND | 100 % | 5 | 
Words with a meaning similar to the clue: Affect radically
These words may or may not be a possible solution to this crosswords clue.- transform
 - change
 - alter
 - alteration
 - changing
 - converted
 - altering
 - altered
 - changer
 - tunable
 - modified
 - turn into
 
Crossword Answer definitions
UPEND verb- To end up; to set on end.
 - To tip or turn over.
 - To destroy, invalidate, overthrow, or defeat.
 
More crossword clues leading to the same solutions
Here's a few more crossword clues - all leading to the identical solution